Such a common metadata representation of scientific claims, argument, evidence and annotation in biomedi- cine should serve as an integrating point for the original publication, subsequent annotations, and all other com- putational methods, supporting a single framework for activities in the nine point cycle of authoring-publishing- consumption-reuse we discuss in the section on Use Cases. This cycle can be thought of as an information value chain in science. This means that each set of dis- parately motivated and rewarded activities, carried out by various actors, creates and passes along value to the next, which consumes this value-added product as an in- put.